Good morning allWe may get an Announcement on Monday - because...

Good morning all

We may get an Announcement on Monday - because the Clinical Trial for CF33 CHECKvacc is now listed on the City of Hope website:

"A Phase I, First-In-Human, Open-Label, Non-Randomized, Dose-Escalating, Single-Center Phase I Study of Intratumoral Administration of CF33-HNIS-AntiPDL1, A Novel Chimeric Oncolytic Poxvirus Encoding Human Sodium Iodide Symporter (HNIS) in Patients with Metastatic Triple Negative Breast Cancer:
Source: https://oncore.coh.org/sip/SIPMain#

The TGA's IND approval was back on 2 July, and LC has previously stated that we were waiting on the City of Hope Ethics Committee for approval to proceed - so it looks like that has now happened.

This is extremely good news. The CF33 pre-clinical results were outstanding. Now we can find out what happens in patients.

This is only a Phase 1 trial, but if if CF33 really does work in humans then the results should be quite dramatic. An Oncolytic Virus will move much faster than Immunotherapy - which takes time for the body to develop the immune response. In fact Checkvacc is the best of both worlds. In pre-clinical studies the CF33 virus has been shown to be massively effective at even tiny doses - finding and destroying cancer cells. However it is also armed with an anti PDL1 immune checkpoint inhibitor - which will make the cancer cells "visible" to the immune system and opens them to attack that way as well.

The original Company announcement of the IND approval contains a bit more background on the trial: https://hotcopper.com.au/threads/ann-fda-ind-approval-of-new-oncolytic-virotherapy-checkvacc.6141869/

Good times ahead. Have a happy weekend all!

Cheers

Dave