In summary, this study described the relatively complete IDD...

In summary, this study described the relatively complete IDD through correlation analysis of rat and human metabolomics (mass spectrometry metabolomics and NMR metabolomics) combined with imaging, molecular biology, and histopathology verification. The findings of this study show tissue metabolism during degeneration. The findings showed that the process of IDD is closely related to the functional state of the Gly-Ser-Thr metabolic axis. Changes in carbohydrate utilization patterns around this metabolic axis and reduction of the antioxidant capacity of the IVD environment promote degeneration. The process eventually leads to disintegration of the annulus fibrosus and loss of water-fixing groups.\

Exciting if they show improvement in this new area of imaging !