This study demonstrates that plasma neurofilament is perhaps...

This study demonstrates that plasma neurofilament is perhaps equally or even more valuable measurement than that in CSF. This will make the follow-up of these patients more simple. Plasma alpha-synuclein is not reported in spite it is included in the ph 2 studies. The data of this study will be used when we get the results of the open phase 2 study. The main point is if ATH434 can reduce plasma neurofilament light or prevent the increase of it as found in this abstract.
At this time most of the open-study patients have been followed for 6 months. Their PPS and UMSARS recordings and neurofilament readings are known both at 3 months and 6 months. I would think that there is also a brain MRI scan at 6 months, so on any day they can inform us if ATH434 reduces iron content, plasma neurofilament light, and improves PPS and UMSARS. Iron content was down after 3 months of treatment in the ape study and all other animal studies done with ATH434. Why would it be different in humans? But anything is possible. That is why we need to know and not only believe. Stamler is much more conservative than I am. So we are waiting, perhaps until summer.