clarifying comment from rudy tanzi, page-27

Front. Psychiatry, 02 March 2012 | doi: 10.3389/fpsyt.2012.00015

Metal chaperones: a holistic approach to the treatment of Alzheimer’s disease
Paul Anthony Adlard* and Ashley Ian Bush
The Mental Health Research Institute, University of Melbourne, Parkville, VIC, Australia
As evidence for the role of metal ion dysregulation in the pathogenesis of multiple CNS disorders grows, it has become important to more precisely identify and differentiate the biological effects of various pharmacological modulators of metal ion homeostasis. This is particularly evident in disorders such as Alzheimer’s disease (AD), where the use of metal chaperones (that transport metals), as opposed to chelators (which exclude metals from biological interactions), may prove to be the first truly disease modifying approach for this condition. The purpose of this mini-review is to highlight the emerging notion that metal chaperones, such as PBT2 (Prana Biotechnology), modulate a variety of critical pathways affecting key aspects of the AD cascade to provide a more “holistic” approach to the treatment of this disease.


Google this and you might understand how PBT2 works