Scientists start clinical trial to test new prostate cancer vaccine
Published on March 1, 2016 at 3:55 AM ·
Oxford University scientists have started a clinical trial to test a new vaccine against prostate cancer and are looking for volunteers to take part. The first four participants have already received this experimental vaccine at the Churchill Hospital in Oxford, and the second trial site has just been opened at the Royal Hallamshire Hospital in Sheffield.
In an initial study led by Professor Freddie Hamdy in Oxford and Professor Jim Catto in Sheffield, the team will vaccinate 48 men with low or intermediate risk prostate cancer to document the safety of the new vaccine and measure how well the immune system to responds to it. If successful, then future larger-scale studies will assess the effectiveness of the vaccine.
Prostate cancer is the most common cancer in men in the UK, affecting 1 in 8 men and causing more than 10,000 deaths each year.
Dr Irina Redchenko, a senior investigator on the trial from the Jenner Institute explained: 'Cancers can spread in the body is because the immune system does not recognise the cancer cells as foreign and so does not attack them. The right type of vaccine could help the body to attack and destroy the cancer cells.'
The vaccine technology being used is based on an immunisation approach developed at Oxford for preventive vaccination and found to be very effective for inducing strong cellular immunity to prevent diseases such as malaria, HIV and Ebola. In this trial it is being assessed for the first time as a cancer vaccine therapy. The vaccines are designed to make the immune system recognise a protein found on the surface of cancer cells which is called 5T4. One of the vaccine components, based on the MVA vaccine vector has already been evaluated in over 500 cancer patients. The other vaccine is a new agent developed in Oxford, called ChAdOx1.5T4, which is being tested for the first time in people.
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