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24/12/20
18:34
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Originally posted by Apocalypso
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There is a reason why the smarter exosome companies are developing engineered exosomes, i.e. using exosomes as a packaging and delivery device for a specific drug cargo, rather than " native" exosomes in their own right: ".... cancer cellsrelease exosomes at an elevated level and their cargos are particularlysuitable for cancer progression...." (ref: Kalluri, J.Clin.Invest 126). And more: "Cancerprogression is a complicated process and exosomes seem to beinvolved in every stage in the development...". "Besides altering the local tumor microenvironment to promotecancer proliferation, tumor derived exosomes are shown to facilitatemetastasis at distant organs..." (ref: Singh, Mol. Cancer 13). And none of these companies seem to be particularly in need of EX1's manufacturing process. So go on and DYOR.
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They are doing EEVs, and even a cursory glance would tell you they aren't utilising naive EVs from tumours (why would anyone use that as a cancer treatment?). So, go on and do some research before writing factually incorrect tripe.