The role of coffee and tobacco has been known for years, but aspirin is new to me as is the polygenic score.

Sci Rep

. 2024 Jun 25;14(1):14670.

doi: 10.1038/s41598-024-65640-x.

The combined effect of lifestyle factors and polygenic scores on age at onset in Parkinson's disease

Carolin **bert ¹, Leonie Blöbaum ¹, Theresa Lüth ¹, Inke R König ², Amke Caliebe ³, Sebastian Sendel ³, Björn-Hergen Laabs ², Christine Klein ¹, Joanne Trinh ⁴

Affiliations expand

• PMID: 38918550

DOI: 10.1038/s41598-024-65640-x

Abstract

The objective of this study was to investigate the association between a Parkinson's disease (PD)-specific polygenic score (PGS) and protective lifestyle factors on age at onset (AAO) in PD. We included data from 4367 patients with idiopathic PD, 159 patients with GBA1-PD, and 3090 healthy controls of European ancestry from AMP-PD, PPMI, and Fox Insight cohorts. The association between PGS and lifestyle factors on AAO was assessed with linear and Cox proportional hazards models. The PGS showed a negative association with AAO (β = - 1.07, p = 6 × 10^-7) in patients with idiopathic PD. The use of one, two, or three of the protective lifestyle factors showed a reduction in the hazard ratio by 21% (p = 0.0001), 44% (p < 2 × 10^-16), and 55% (p < 2 × 10^-16), compared to no use. An additive effect of aspirin (β = 7.62, p = 9 × 10^-7) and PGS (β = - 1.58, p = 0.0149) was found for AAO without an interaction (p = 0.9993) in the linear regressions, and similar effects were seen for tobacco. In contrast, no association between aspirin intake and AAO was found in GBA1-PD (p > 0.05). In our cohort, coffee, tobacco, aspirin, and PGS are independent predictors of PD AAO. Additionally, lifestyle factors seem to have a greater influence on AAO than common genetic risk variants with aspirin presenting the largest effect.


https://www.nature.com/articles/s41598-024-65640-x