In a criminal trial, the accused is innocent until proven guilty. The burden of proof is on the prosecution, with the assumption that the accused is innocent.
In a scientific trial, the burden of proof is on the company to prove the treatment works, with the assumption that it doesn't work, the "null hypothesis". Here the company and especially the shareholders are actually asking the FDA to prove their treatment doesn't work.
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- Conflict of Interest Evidence Thread - C. Hinrichs in ODAC Meeting
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