Look at the corporate experience of those making the decision - these fellows are not amateurs.
The original aim was progressive free survival. This was achieved successfully against an extremely agressive cancer (naive B cell lymphoma) but with one of the dogs there was a huge surprise, major tumour regression. This dog had lower level of the drug in its blood than the others. With further lab research, they now think its because this medication is bi-phasic. So if they can reproduce the results of that dog in others by using a lower dose, then they've got a "block buster" on their hands.
Anyway everybody who's interested should see the AGM video in full to understand what they are up to:
https://pharmaust.com/pharmaust-videos/
Including Buckland, since he was too busing to be bothered with finding out or even getting off his backside and asking and forwarding questions.
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