Just some additional information from the Biotron Influenza...

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    Just some additional information from the Biotron Influenza Patent supporting what you have stated.

    METHODS OF TREATING INFLUENZA

    The present invention relates to the treatment or prevention of influenza virus infection. In particular, the present invention relates to antiviral compounds and their use in the treatment or prevention of influenza virus infection.

    Standard influenza vaccines have to be redesigned each year to counter new variants of the virus. In addition, any immunity provided is short-lived. Therefore, vaccines may not prevent or limit a pandemic if the circulating strains continue to drift significantly, or another subtype emerges. Instead, antiviral agents will be critical for initial control and protection against an emerging pandemic.

    Previously, N-carbamimidoyl-5-(1-methyl-1H-pyrazol-4-yl)-2-naphthamide (BIT225) has been shown to have only limited activity against the M2 viroporin of influenza A and was not considered to be suitable for treating influenza (Jalily et al., MolPharm, 2016. 90: 80-95).

    However, the present application surprisingly shows that BIT225 has activity against multiple subtypes and strains of influenza virus.

    Importantly, BIT225 has been found to have activity against subtypes and strains that are resistant to amantadine.According to another aspect, the present invention provides use of (BIT225) ( N-carbamimidoyl-5-(1-methyl-1H-pyrazol-4-yl)-2-naphthamide, or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for the treatment or prevention of influenza virus infection.

    Although for influenza, its interesting to note that "a pharmaceutically accepted salt" includes : ribavarin, acyclovir, ganciclovir and zidovudine - all of these are being tested for effectiveness against Covid-19.

    The present invention provides materials and methods for preventing and/or treating viral infections. Specifically, the subject invention provides materials and methods for preventing influenza infection; treating/ameliorating symptoms associated with influenza infections; and/or preventing/delaying the onset of complications associated with influenza infections.

    As we are in the middle of Covid-19 pandemic and putting on full display the shortfalls of not having a "cure" in the wings, if a flu pandemic does arrive (scary thought) I wonder if that will hasten the need for clinical trials for BIT225 with the varying flu strains?
 
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