Given that there has been a lot of reference to the 1918 "flu" I thought this article from the new scientist (2008) is very interesting
“We agree completely that bacterial pneumonia played a major role in the mortality of the 1918 pandemic,” says Anthony Fauci, director of National Institute for Allergy and Infectious Disease in Bethesda, Maryland, and author of another journal article out next month that comes to a similar conclusion.