Cancer SARS-CoV-2 Vaccination and the Multi-Hit Hypothesis of...

Cancer

• SARS-CoV-2 Vaccination and the Multi-Hit Hypothesis of Oncogenesishttps://www.cureus.com/articles/209584-sars-cov-2-vaccination-and-the-multi-hit-hypothesis-of-oncogenesis#!/
  (A major journal just published a peer-reviewed paper listing eight different ways the vaccines can cause new cancers or make regressed cancers flare up again. The authors then said that since there was so much evidence the jabs promote cancer, the drugmakers should be forced to prove the shots don’t cause cancer in order to continue. “This comprehensive literature review aims to highlight the potential that COVID-19 genetic vaccines, particularly mRNA vaccines, have to fulfill the multi-hit hypothesis of oncogenesis as originally proposed by Sutherland and Bailor in 1984, in that they elicit a pro-tumorigenic milieu favorable to cancer progression and/or (metastatic) recurrence.” Explanatory article here.)

• Transfected SARS-CoV-2 spike DNA for mammalian cell expression inhibits p53 activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2 proteins in cancer cells and increases cancer cell viability after chemotherapy exposure
  https://www.oncotarget.com/article/28582/text/
  (According to the study, spike protein may promote cancer survival and growth through blocking the function of a crucial cancer suppressor gene known as p53. The gene—the most commonly affected by cancer—stops cancer cell growth and encourages DNA repair. Researchers also found that cancer cells containing spike protein subunits displayed increased resistance to chemotherapy. “We saw enhanced cancer cell viability in the presence of SARS-CoV-2 spike S2 subunit after treatment with several chemotherapy agents.” Explanatory articles herehere.)

• Oncogenesis and autoimmunity as a result of mRNA COVID-19 vaccination
  https://www.authorea.com/users/455597/articles/737938-oncogenesis-and-autoimmunity-as-a-result-of-mrna-covid-19-vaccination
  (Study shows that repeated injections of mRNA COVID-19 vaccines are taking down immune surveillance for nascent malignant cells while at the same time inducing autoimmunity. Explanatory article here.)

• Types and Rates of COVID-19 Vaccination in Patients With Newly Diagnosed Microsatellite Stable and Instable Non-Metastatic Colon Cancerhttps://www.cureus.com/articles/260109-types-and-rates-of-covid-19-vaccination-in-patients-with-newly-diagnosed-microsatellite-stable-and-instable-non-metastatic-colon-cancer#!/
  (Exposure to the Pfizer mRNA COVID-19 vaccine was associated with a > 6-fold increased risk for this form of cancer. “In this case-control study, we revealed that the mRNA-based COVID-19 vaccine is associated with dMMR non-metastatic colon cancer. The BNT162b2 vaccine is associated with the higher risk of dMMR non-metastatic colon cancer” Explanatory article here. )

• Review: N1-methyl-pseudouridine (m1Ψ): Friend or foe of cancer?
  https://www.sciencedirect.com/science/article/abs/pii/S0141813024022323
  (“it has been discovered that the mRNA vaccines inhibit essential immunological pathways, thus impairing early interferon signaling. Within the framework of COVID-19 vaccination, this inhibition ensures an appropriate spike protein synthesis and a reduced immune activation. Evidence is provided that adding 100 % of N1-methyl-pseudouridine (m1Ψ) to the mRNA vaccine in a melanoma model stimulated cancer growth and metastasis, while non-modified mRNA vaccines induced opposite results, thus suggesting that COVID-19 mRNA vaccines could aid cancer development.” Explanatory article here.)

• SARS-CoV-2 spike S2 subunit inhibits p53 activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2 proteins in cancer cells
  https://www.biorxiv.org/content/10.1101/2024.04.12.589252v1.full
  (“In summary, we identified the SARS-CoV-2 spike S2 subunit as a factor that interrupts p53 binding to MDM2 in cancer cells and demonstrated the suppressive effect of SARS-CoV-2 spike S2 on p53 signaling in cancer cells. As loss of p53 function is a known driver of cancer development and confers chemo-resistance, our study provides insight into cellular mechanisms by which SARS-CoV-2 spike S2 may be involved in reducing barriers to tumorigenesis” Explanatory article here.)

• The impact of BNT162b2 mRNA vaccine on adaptive and innate immune responses
  https://www.medrxiv.org/content/10.1101/2021.05.03.21256520v2
  (explanatory article: “These COVID-19 mRNA injectable products are causing, yes, causing, immune system dysregulation - and not just in the context of the adaptive system, but in the context of the innate system. Not only that, but these findings provide very good reasons as to why we are seeing resurgences of latent viral infections and other adverse events.”)

• S2 subunit of SARS-nCoV-2 interacts with tumor suppressor protein p53 and BRCA: an in silico study
  https://pubmed.ncbi.nlm.nih.gov/32619819/
  (An in silico modeling study that concluded the S2 segment of the SARS-CoV-2 Spike protein could be anticipated to inhibit the p53 and BRCA1/2 tumor surveillance systems. Importantly, the S2 segment has not been found in the body after the infection, however, it is readily produced in large quantities after mRNA COVID-19 vaccination. This suggests C19 infection may not promote cancer growth but C19 vaccine injections may. Explanatory article here.)

• The CD147 Epitope on SARS CoV2 and the Spike in Cancer, Autoimmunity and Organ Fibrosishttps://www.qeios.com/read/S86J75
  ("TNFα in partnership with glycosylated CD147 conspires to create the fertile soil for de novo and recurrent cancer. CD147 is present on the spike protein S (virus or vaccine) despite claims to the contrary." Also, "Booster doses and recurrent infections repeatedly stoke the production of TNFα, associated with the spike in the aggressive triple negative form of breast cancer")

• Increased Age-Adjusted Cancer Mortality After the Third mRNA-Lipid Nanoparticle Vaccine Dose During the COVID-19 Pandemic in Japan
  https://assets.cureus.com/uploads/original_article/pdf/196275/20240408-14533-1avkjxd.pdf
  ("Conclusions: Statistically significant increases in age-adjusted mortality rates of all cancer and some specific types of cancer, namely, ovarian cancer, leukemia, prostate, lip/oral/pharyngeal, pancreatic, and breast cancers, were observed in 2022 after two-thirds of the Japanese population had received the third or later dose of SARS- CoV-2 mRNA-LNP vaccine. These particularly marked increases in mortality rates of these ERα-sensitive cancers may be attributable to several mechanisms of the mRNA-LNP vaccination rather than COVID-19 infection itself or reduced cancer care due to the lockdown.")