Eye DisordersCharacteristics and Clinical Ocular Manifestations...

Eye Disorders

• Characteristics and Clinical Ocular Manifestations in Patients with Acute Corneal Graft Rejection after Receiving the COVID-19 Vaccine: A Systematic Reviewhttps://www.mdpi.com/2077-0383/11/15/4500
  (Cornea grafts are considered a much lower-risk transplant procedure than solid organ transplants with a much lower rejection rate. Thus, researchers were surprised to find a total of 23 eyes from 21 patients who had undergone corneal graft procedures who experienced rejection anywhere from one day to six weeks following COVID vaccination. In some cases, the rejection occurred suddenly after being jabbed despite the cornea graft having held steady for many years. Explanatory article here.)

• Risk assessment of retinal vascular occlusion after COVID-19 vaccination
  https://www.nature.com/articles/s41541-023-00661-7
  (Following vaccination, there is a prolonged increased risk of retinal vascular occlusion in all ages. Over two years, the risk of RVO is doubled. Explanatory articles here and here.)

• COVID-19 Vaccine-Associated Optic Neuropathy: A Systematic Review of 45 Patients
  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609672/pdf/vaccines-10-01758.pdf
  (Description of an injury pattern in which lipid nanoparticles settle along the artery or into the central nerve taking visual signals to the brain, then inflammation fighting the foreign Spike protein that starts a process of tissue damage leading to loss of vision.)

• The Eye of the Storm: COVID-19 Vaccination and the Eye
  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675299/
  (A literature review consisting mainly of case reports and case series, representing possible ocular side effects associated with COVID-19 vaccines.)

• Ocular Complications Following Vaccination for COVID-19: A One-Year Retrospectivehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875181/
  (“Since the introduction of COVID-19 vaccinations, numerous reports have commented on adverse ocular events following vaccination. In this review, we sought to present these in a systematic fashion and offer insights into the mechanisms and clinical considerations surrounding these phenomena.”)

• UVEITIS AFTER THE BNT162b2 mRNA VACCINATION AGAINST SARS-CoV-2 INFECTION: A Possible Associationhttps://pubmed.ncbi.nlm.nih.gov/34369440/
  (Uveitis may develop after the administration of the BNT162b2 mRNA vaccine. The most common complication was mild to moderate anterior uveitis.)

• Retinal Toxicity of Polyethylene Glycol (PEG)-400https://iovs.arvojournals.org/article.aspx?articleid=2359098
  (Study concludes that the intravitreal injection of polyethylene glycol-400 is toxic to retina and it should not be used as a vehicle in the eye.)

Increased Susceptibility to C19 Infection

• Risk of SARS-CoV-2 infection and hospitalization in individuals with natural, vaccine-induced and hybrid immunity: a retrospective population-based cohort study from Estonia
  https://www.nature.com/articles/s41598-023-47043-6
  (“Individuals with vaccine-induced immunity were at higher risk than those with natural immunity for infection and hospitalization. Vaccination made risks worse particular during the Delta wave.” Explanatory article here.)

• IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein
  https://www.mdpi.com/2076-393X/11/5/991
  (“… emerging evidence suggests that the reported increase in IgG4 levels detected after repeated vaccination with the mRNA vaccines may not be a protective mechanism; rather, it constitutes an immune tolerance mechanism to the spike protein that could promote unopposed SARS-CoV2 infection and replication by suppressing natural antiviral responses… repeated mRNA vaccination may also cause autoimmune diseases, and promote cancer growth and autoimmune myocarditis in susceptible individuals.” Explanatory article here.)

• Forgotten “Primum Non Nocere” and Increased Mortality after COVID-19 Vaccination
  https://www.primescholars.com/articles/forgotten-primum-non-nocere-and-increased-mortality-after--covid19-vaccination.pdf
  (“Calculations confirm that the mortality of the vaccinated coronavirus infected groups was 14.5% higher on average than the mortality of non-vaccinated coronavirus infected groups. Conclusion: Vaccinated infected groups appear to have higher average mortality than their non-vaccinated infected counterparts.”)

• Effectiveness of the Coronavirus Disease 2019 Bivalent Vaccine
  https://academic.oup.com/ofid/article/10/6/ofad209/7131292?login=false
  (Known as the Cleveland Clinic study, it shows that the chances of contracting COVID-19 increase with each additional dose of COVID-19 vaccine. See figure 2 of the study. Basically, the more jabs, the more and faster the covid infections. Over a 90 day period participants with 3 or more doses faced a risk of catching COVID up to 6x than the baseline. Every dose proportionately increased the risk of infection, strongly suggesting correlation.)

• Antinucleocapsid Antibodies After SARS-CoV-2 Infection in the Blinded Phase of the Randomized, Placebo-Controlled mRNA-1273 COVID-19 Vaccine Efficacy Clinical Trial
  https://www.acpjournals.org/doi/10.7326/M22-1300
  (This paper points out that the more times people are vaccinated, the less likely they are to develop broad-based immunity when they get the actual virus. What this means is the more vaccines you get, the less likely you are to develop full immunity from the virus.)

• Effectiveness of mRNA-1273 vaccination against SARS-CoV-2 omicron subvariants BA.1, BA.2, BA.2.12.1, BA.4, and BA.5
  https://www.nature.com/articles/s41467-023-35815-7
  (A Kaiser Permanganate study that shows negative efficacy of the shots against all variants within 150 days. And this study shows the more you inject, the more you infect; specifically, over time, those with three doses fare worse than those with two.)

• Class switch toward noninflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination
  https://www.science.org/doi/10.1126/sciimmunol.ade2798
  (Study suggests that vaccinated people may be developing a systemic tolerance for toxic spike protein. To put it simply, this antibody class shift is bizarre, unprecedented, and a very troubling sign that vaccinated people—especially repeatedly dosed people—are somehow losing their IgG1 and especially IgG3 response in favor of IgG4. Meaning it’s a reduction of the two effective neutralizing antibody types, and increase in the least effective type IgG4, which is actually for allergies and doesn’t remove the foreign proteins so much as teach the body to “tolerate” or “ignore” them. Specifically, whereas IgG1 and IgG3 types are “pro-inflammatory,” which means they trigger the body’s immune-system high alert system, the IgG4 type is “anti-inflammatory,” which means it tells the immune system to stand down. Which is the opposite of what you really want, when you’re fighting an infection.)

• Conserved longitudinal alterations of anti-S-protein IgG subclasses in disease progression in initial ancestral Wuhan and vaccine breakthrough Delta infections
  https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.1043049/full
  (Just like the above study, researchers found higher ratios of IgG4 were associated with more severe disease, and people who had high levels of IgG4 antibodies relative to IgG3 had worse clinical outcomes, meaning they got sicker.)

• Duration of Shedding of Culturable Virus in SARS-CoV-2 Omicron (BA.1) Infection
  https://www.nejm.org/doi/full/10.1056/NEJMc2202092
  (Study shows that boosted subjects cleared the virus more slowly than unvaccinated people, and that the share of boosted subjects who were still contagious (31%) at day ten was over five times more than the share of still-contagious unvaccinated subject (6%).)

• Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure
  https://www.science.org/doi/10.1126/science.abq1841
  (“This “hybrid immune damping” indicates substantial subversion of immune recognition and differential modulation through immune imprinting and may be the reason why the B.1.1.529 (Omicron) wave has been characterized by breakthrough infection and frequent reinfection with relatively preserved protection against severe disease in triple-vaccinated individuals.”)

• Increases in COVID-19 are unrelated to levels of vaccination across 68 countries and 2947 counties in the United States
  https://link.springer.com/article/10.1007/s10654-021-00808-7
  (In fact, the trend line suggests a marginally positive association such that countries with higher percentage of population fully vaccinated have higher COVID-19 cases per 1 million people.)

• Informed consent disclosure to vaccine trial subjects of risk of COVID-19 vaccines worsening clinical disease
  https://onlinelibrary.wiley.com/doi/10.1111/ijcp.13795
  (Vaccines designed empirically using the traditional approach, be they composed of protein, viral vector, DNA or RNA and irrespective of delivery method, may worsen COVID‐19 disease via antibody‐dependent enhancement (ADE). This risk is sufficiently obscured in clinical trial protocols and consent forms for ongoing COVID‐19 vaccine trials that adequate patient comprehension of this risk is unlikely to occur, obviating truly informed consent by subjects in these trials.)

• Effects of Vaccination and Previous Infection on Omicron Infections in Children
  https://www.nejm.org/doi/full/10.1056/NEJMc2209371
  (Study shows that children who had Covid and were subsequently vaccinated, were much more likely to get reinfected than their peers who also had Covid, and were NOT vaccinated. In other words, for kids who had Covid, getting them vaccinated made them much more susceptible to reinfections. Explanatory article here)

• (SARS-CoV-2) Naturally Acquired Immunity versus Vaccine-induced Immunity, Reinfections versus Breakthrough Infections: A Retrospective Cohort Study
  https://academic.oup.com/cid/article/75/1/e545/6563799
  (As demonstrated in this paper, people whose immune response was induced by Pfizer’s mRNA product—versus natural immunity—were at 13-times greater risk of being infected with SARS-CoV-2. Explanatory article here.)

• Severity of SARS-CoV-2 Reinfections as Compared with Primary Infections
  https://www.nejm.org/doi/10.1056/NEJMc2108120
  (explanatory article: “These data show show that the vaccinated are 10.29 mores likely to suffer from severe or critical COVID-19 or death upon reinfection than those with natural immunity.”)

• Elevated risk of infection with SARS-CoV-2 Beta, Gamma, and Delta variant compared to Alpha variant in vaccinated individuals
  https://pubmed.ncbi.nlm.nih.gov/35862508/
  (Study shows increased risk of infection in the vaccinated. Explanatory article)