Reverse Transcription of the Genome
Methodological Considerations Regarding the Quantification of DNA Impurities in the COVID-19 mRNA Vaccine Comirnaty®
https://www.mdpi.com/2409-9279/7/3/41
(“The available information and data indicate that the ready-to-use mRNA vaccine Comirnaty contains DNA impurities that exceed the permitted limit value by several hundred times and, in some cases, even more than 500 times. Further, DNA impurities in Comirnaty® are apparently integrated into the lipid nanoparticles and are thus transported directly into the cells of a vaccinated person, just like the mRNA active ingredient. What this means for the safety risks, particularly the possible integration of this DNA into the human genome, i.e., the risk of insertional mutagenesis, should be a secondary focus”)Presence of viral spike protein and vaccinal spike protein in the blood serum of patients with long-COVID syndrome
https://www.europeanreview.org/article/34685
(These findings are unsettling and show that some vaccinated people experience forced alteration of their genomes, with spike protein-producing code permanently residing in the affected cells--despite that “Covid vaccine changes our genome” was considered an anti-science anti-vax trope and was constantly ridiculed by Pfizer-sponsored press. Explanatory article here.)DNA fragments detected in monovalent and bivalent Pfizer/BioNTech and Moderna modRNA COVID-19 vaccines from Ontario, Canada: Exploratory dose response relationship with serious adverse events.
https://osf.io/preprints/osf/mjc97
(The largest data set to date on this topic, using vials from multiple Canadian batches of both the Pfizer and Moderna shots. Every single one was contaminated with bacterial DNA. Also confirmed the presence of the SV40 enhancer sequence in the contaminating DNA in Pfizer’s Canadian vials. Explanatory articles here and here.)Sequencing of bivalent Moderna and Pfizer mRNA vaccines reveals nanogram to microgram quantities of expression vector dsDNA per dose
https://osf.io/preprints/osf/b9t7m
(DNA contamination can contribute to interference with the human genome. This study found DNA contamination that far exceeds the European Medicines Agency (EMA) and the FDA’s requirements. “Studies evaluating the reverse transcriptase activity of LINE-1 and vaccine mRNA will need to account for the high levels of DNA contamination in the vaccines.” Explanatory article here.)SARS-CoV-2 RNA reverse-transcribed and integrated into the human genomehttps://www.biorxiv.org/content/10.1101/2020.12.12.422516v1
(MIT & Harvard study [preprint] suggest mRNA might permanently alter DNA after all. “To experimentally corroborate the possibility of viral retro-integration, we describe evidence that SARS-CoV-2 RNAs can be reverse transcribed in human cells by reverse transcriptase (RT) from LINE-1 elements or by HIV-1 RT, and that these DNA sequences can be integrated into the cell genome and subsequently be transcribed.” Explanatory article here.)Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Linehttps://www.mdpi.com/1467-3045/44/3/73
(The CDC insisted “mRNA never enters the nucleus of the cell where our DNA is located, so it cannot change or influence our genes," and yet this in vitro study found the spike protein instructions being incorporated into cells’ own DNA, in a process called “reverse transcription" that takes place "in as fast as 6 hours upon exposure.” This means a body could produce spike protein forever, or, if the body treats these rewired cells as cancerous, it could trigger autoimmune diseases. Finally, modified sperm or egg cells could pass the mutated DNA into parents' children’s cells.)mRNA: Vaccine or Gene Therapy? The Safety Regulatory Issues
https://www.mdpi.com/1422-0067/24/13/10514
(“The wide and persistent biodistribution of mRNAs and their protein products, incompletely studied due to their classification as vaccines, raises safety issues. Post-marketing studies have shown that mRNA passes into breast milk and could have adverse effects on breast-fed babies. Long-term expression, integration into the genome, transmission to the germline, passage into sperm, embryo/fetal and perinatal toxicity, genotoxicity and tumorigenicity should be studied in light of the adverse events reported in pharmacovigilance databases.”)
