Researchers from the University of Oxford have today reported on findings on the vaccinated people who are at greatest risk from severe COVID-19 leading to hospitalisation or death from 14 days post the second dose vaccination, when substantial immunity should be expected.
...... the researchers have developed cumulative risk scores to calculate people's risk of hospitalisation or death from COVID-19 following one, or two vaccination doses. These scores take into account factors including age, sex, ethnic group and the background rate of COVID infections, and in particular highlight an elevated risk to:
Those who are immunosuppressed as a result of chemotherapy, a recent bone marrow or solid organ transplant, or HIV/AIDS
People with neurological disorders, including dementia and Parkinson's
Care home residents, and those with chronic disorders including Down's Syndrome
'This enormous national study of over 5 million people vaccinated with 2 doses across the UK has found that a small minority of people remain at risk of COVID-19 hospitalisation and death. Our risk calculator helps to identify those who remain most at risk post-vaccination.'
'Our new QCovid tool, developed with the help of experts from across the UK, has been designed to identify those at high risk who may benefit from interventions such as vaccine booster doses or new treatments such as monoclonal antibodies, which can help reduce the risk of progression SARS-CoV-2 infection to serious COVID-19 outcomes.'
The researchers hope that these data can be used in a variety of health and care settings to inform those more likely to be at risk, and potentially help to prioritise those identified for further trials of vaccines, boosters or future preventative therapies.
