Links between CRVx and SSH
CRVx (nervous system) in HF and Hypertension same as SSH (blood)
Abrahams has a lead involvement with both.
Dimitrios "Jim" Georgakopoulos Chief scientific Officer SSH ex. research fellow CRVx
Silicon Valley Bank providing finance for both CRVx and SSH
*** http://www.cvrx.com/usa_news/cvrx-secures-15-million-growth-capital-facility-silicon-valley-bank/ ***
Both twin city companies.
More on CCRVx
http://www.cvrx.com/usa/healthcare/hypertension/barostim-neo/
Barostim neo is designed to take advantage of the body’s natural baroreflex system which provides important monitoring and feedback for blood flow throughout the body. It activates baroreceptors in the wall of the carotid artery which stimulate the afferent and efferent pathways of the autonomic nervous system. To lower excessive blood pressure the brain responds by modulating efferent pathways, which relaxes the blood vessels, slows the heart rate and reduces fluid in the body. These actions reduce the afterload on the heart by decreasing arterial resistance, which improves the heart’s ability to pump blood to the tissues. The increase in parasympathetic tone and decrease in sympathetic drive results in the restoration of sympathetic-vagal balance which reduces excessive blood pressure and improves cardiac structure and function.
Salutary tale on superseded/orphaned trial device and the dangers for trial participants.
http://www.thestate.com/news/local/article15504644.html
Failed medical device trial leaves Gilbert man facing death
Recently published trial results for CRVx Barostim Neo
http://www.sciencedirect.com/science/article/pii/S2213177915001250
QOL scores comparable with C-Pulse , 6 minute walk , CRVx better.
Since Hospitalisations and NYHA improvements are only hinted at but not delved into with CRVx, I'm assuming C-Pulse's results were far better.
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Was a bad baroreflex system result suspected with some adverse C-Pulse events?
Explain delays?
Anyway Silicon Valley Banks involvement indicates problems if any are controlled.
Rising pipeline indicates implant arm patients doing well.
The Baroreflex system is a looped system with action and feedback.
Not just about pumping blood as some LVAD fans solely base efficacy on.
Would be other feedback systems as well.
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