CU6 - ASX Charts, page-2122

If someone like flotsam222 who to me a sophisticated investor with lots of experience, could get confused between [64Cu]-DOTAGA-PSMA and [⁶⁴Cu]-SAR-BisPSMA, i wonder how many out there still in the same boat with this confusion

The most important thing in [⁶⁴Cu]-SAR-BisPSMA is SAR chelator, that binds the CU isotopes so that it does not get leaked into the body

	Feature	SAR Chelator	Older Chelators (e.g., DOTAGA, DOTA)
1	Copper Binding Strength	Very high, ultra-stable	Moderate (some copper leakage)
2	Stability In Vivo	Very stable (even at 48h)	Degrades or dissociates over time
3	Tumor Imaging Quality	High tumor contrast, low background	More background uptake
4	Suitability for Therapy (Cu-67)	Excellent	Poor (unstable for long-term therapy)
5	Temperature Resistance	Stable in biological conditions	Some are heat-sensitive
6	Charge and Solubility	Tuned for human blood chemistry	Less optimized

The Next important thing in [⁶⁴Cu]-SAR-BisPSMA is Bis

	Molecule	Number of PSMA Binding Arms	Effect
1	PSMA-11 (Illuccix)	1	Good binding, but can detach faster
2	SAR-BisPSMA	2 (bispecific)	Much stronger and more stable binding to tumor cells