CU6 - ASX Charts, page-2123

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ma420

8,242 Posts.

2061

26/04/25

17:07

Post #: 78809472

Originally posted by jinvstr: ↑
If someone like flotsam222 who to me a sophisticated investor with lots of experience, could get confused between [64Cu]-DOTAGA-PSMA and [⁶⁴Cu]-SAR-BisPSMA, i wonder how many out there still in the same boat with this confusion

The most important thing in [⁶⁴Cu]-SAR-BisPSMA is SAR chelator, that binds the CU isotopes so that it does not get leaked into the body
Feature SAR Chelator Older Chelators (e.g., DOTAGA, DOTA)
1 Copper Binding Strength Very high, ultra-stable Moderate (some copper leakage)
2 Stability In Vivo Very stable (even at 48h) Degrades or dissociates over time
3 Tumor Imaging Quality High tumor contrast, low background More background uptake
4 Suitability for Therapy (Cu-67) Excellent Poor (unstable for long-term therapy)
5 Temperature Resistance Stable in biological conditions Some are heat-sensitive
6 Charge and Solubility Tuned for human blood chemistry Less optimized

The Next important thing in [⁶⁴Cu]-SAR-BisPSMA is Bis

Molecule Number of PSMA Binding Arms Effect
1 PSMA-11 (Illuccix) 1 Good binding, but can detach faster
2 SAR-BisPSMA 2 (bispecific) Much stronger and more stable binding to tumor cells
Expand
Thanks for posting this. GA’s for both posts.

I wonder what comparisons could be made for Cu67 and how it compares.

Ta

CU6 Price at posting: $2.29 Sentiment: Buy Disclosure: Held

5 Upvote

0 Great analysis

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(20min delay)
Last $2.01		Change -0.070(3.37%)		Mkt cap ! $645.9M

Open	High	Low	Value	Volume
$2.06	$2.06	$1.97	$4.379M	2.177M

Buyers (Bids)

No.	Vol.	Price($)
1	1500	$2.00

Sellers (Offers)

Price($)	Vol.	No.
$2.03	1387	1

View Market Depth

No.	Vol.	Price($)
3	4000	2.140
1	10000	2.040
3	3046	2.020
2	5222	2.000
1	1000	1.990

Price($)	Vol.	No.
1.885	9	1
1.910	6244	1
2.010	1000	1
2.020	235	2
2.040	10000	1

Last trade - 16.11pm 23/06/2025 (20 minute delay)

CU6 (ASX) Chart

	Feature	SAR Chelator	Older Chelators (e.g., DOTAGA, DOTA)
1	Copper Binding Strength	Very high, ultra-stable	Moderate (some copper leakage)
2	Stability In Vivo	Very stable (even at 48h)	Degrades or dissociates over time
3	Tumor Imaging Quality	High tumor contrast, low background	More background uptake
4	Suitability for Therapy (Cu-67)	Excellent	Poor (unstable for long-term therapy)
5	Temperature Resistance	Stable in biological conditions	Some are heat-sensitive
6	Charge and Solubility	Tuned for human blood chemistry	Less optimized

	Molecule	Number of PSMA Binding Arms	Effect
1	PSMA-11 (Illuccix)	1	Good binding, but can detach faster
2	SAR-BisPSMA	2 (bispecific)	Much stronger and more stable binding to tumor cells

CU6 - ASX Charts, page-2123

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ASX Market Open: Futures rocket on 'total and complete' Israel-Iran ceasefire | June 24

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