Lutetium-177 (177Lu) is the radioactive component of 177Lu-PSMA-617. It is classified as a medium-energy beta emitter.Combining enzalutamide with lutetium-177-PSMA-617 for treating metastatic castration-resistant prostate cancer (mCRPC):
Investigating a bit further
More specifically combining enzalutamide with lutetium-177-PSMA-617ENZA-p Trial ResultsThe ENZA-p trial was a phase 2 randomized study comparing enzalutamide alone to enzalutamide plus 177Lu-PSMA-617 in patients with mCRPC. Key results include:Median PSA progression-free survival (PSA-PFS):Combination therapy: 13.0 monthsEnzalutamide alone: 7.8 monthsHazard ratio: 0.43 (95% CI 0.29-0.63, p < 0.0001) PSA response rates: PSA50 (≥50% decrease): 93% for combination vs 68% for enzalutamide alone (p <0 .001)PSA90 (≥ 90% decrease): 78% for combination vs 37% for enzalutamide alone (p < 0.001)Median radiographic PFS:Combination therapy: 16 monthsEnzalutamide alone: 12 monthsHazard ratio: 0.67 (95% CI 0.44-1.01)Safety:Grade 3-5 adverse events: 40% for combination vs 41% for enzalutamide aloneMost common adverse events in combination arm: fatigue (75%), nausea (47%), dry mouth (40%)
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https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045%2824%2900135-9/abstract
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