You wrote, "Obviously the plan did not go well."Care to share...

You wrote, "Obviously the plan did not go well."
Care to share what makes you think that the plan did not go well?


I also noticed your comment about our "mob" 's P1 trial over on the other thread:

https://hotcopper.com.au/threads/banter-and-general-discussion.5410558/page-4718?post_id=63726744

Any chance you could provide a link that shows a comment about Cohort B showing a clinical response on day 3?

I can see that participants had a study visit on day 3 according to the trial design:


https://clinicaltrials.gov/ct2/show/NCT02923375

But I can't see any mention of data being collected and/or presented for that timepoint later on.


Your post also mentions, "What did your boss say about why they would go for the high dose?"
https://hotcopper.com.au/threads/banter-and-general-discussion.5410558/page-4724?post_id=63727240

I know what Kilian Kelly said:


https://app.sharelinktechnologies.com/announcement/asx/176993991ab6cb44f055a76242029f9d

This is an observation that is in line with Galiepau's findings:


https://www.cell.com/cell-stem-cell/pdfExtended/S1934-5909(18)30222-4

It therefore makes sense to use the higher dose which showed a "much quicker treatment response" early on. However, having data as early as day 3 would be very interesting to see as it would allow us to break down the provided data even further, even more than the published article in Nature has done.
https://www.nature.com/articles/s41591-020-1050-x