Just doing some reading/digging on some information from the...

Just doing some reading/digging on some information from the Quarterly report 30th October 2015 :

a) AMG™ Coupling Kit, 200 nm Magnetic Particles

Following the release of the 200nm kit, Anteo engaged US based DCN Diagnostics, a leading, globally recognised company for the commercialisation of high-performance, rapid assay systems, to evaluate the performance of the kit in a lateral flow assay.

Lateral flow assays are commonly used for applications such as pregnancy testing and are being developed for an increasingly wide range of other tests. The study compared the performance of the Mix&Go activated magnetic particles to covalently conjugated magnetic particles in a lateral flow assay that detects human Chorionic Gonadotropin (hCG).

This hormone is used to detect early stage pregnancy and is a well- known and tested model system. The conclusions of the study were:

1. The Anteo Mix&Go based hCG assay is 5 times more sensitive than the covalently conjugated magnetic particle based test using the same critical reagents.

2. The hCG assay using the Anteo Mix&Go particles used half the amount of antibody to achieve better sensitivity than the covalently conjugated particles.

3. The variability of the Anteo Mix&Go based hCG assay is lower than the covalently conjugated hCG assay. There is also less non-specific binding with the Mix&Go particles.

4. The Anteo Mix&Go particles come fully activated and are ready for the antibody conjugation. The covalent conjugation procedure requires steps to wash and activate the particles before the addition of the antibody. The Mix&Go procedure takes less time with fewer steps than the covalent conjugation procedure.

I found the below research paper from DCN Diagnostics interesting reading :

http://www.dcndx.com/source/files/D...ation_Topics in Companion Animal Medicine.pdf

"As technologies evolve, they go through a familiar evolutionary cycle—an S-curve. At the start of the cycle, the basis of the technology is laid out, and there are few users. At a certain inflection point, the number of users of the technology goes exponential, and the number of applications for which it is applied grows at a rapid rate"

"Lateral flow test technology is reaching the center of the Scurve—the point at which the curve inverts. At this “flip” in a technology life cycle, user-centered design takes center stage"