See below Review of Mass Drug Administration for Malaria and Its...

See below
Review of Mass Drug Administration for Malaria and Its Operational Challenges.

Newby G¹, Hwang J², Koita K¹, Chen I¹, Greenwood B¹, von Seidlein L¹, Shanks GD¹, Slutsker L¹, Kachur SP¹, Wegbreit J¹, Ippolito MM¹, Poirot E¹, Gosling R¹.
Author information

• ¹The Malaria Elimination Initiative, Global Health Group, University of California, San Francisco, California; Malaria Branch and Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia; London School of Hygiene and Tropical Medicine, London, United Kingdom; Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand; Australian Army Malaria Institute, Enoggera, Australia; Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland.
• ²The Malaria Elimination Initiative, Global Health Group, University of California, San Francisco, California; Malaria Branch and Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia; London School of Hygiene and Tropical Medicine, London, United Kingdom; Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand; Australian Army Malaria Institute, Enoggera, Australia; Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland [email protected].

Abstract

Mass drug administration (MDA) was a component of many malaria programs during the eradication era, but later was seldomly deployed due to concerns regarding efficacy and feasibility and fear of accelerating drug resistance. Recently, however, there has been renewed interest in the role of MDA as an elimination tool. Following a 2013 Cochrane Review that focused on the quantitative effects of malaria MDA, we have conducted a systematic, qualitative review of published, unpublished, and gray literature documenting past MDA experiences. We have also consulted with field experts, using their historical experience to provide an informed, contextual perspective on the role of MDA in malaria elimination. Substantial knowledge gaps remain and more research is necessary, particularly on optimal target population size, methods to improve coverage, and primaquine safety. Despite these gaps, MDA has been used successfully to control and eliminate Plasmodium falciparum and P. vivax malaria in the past, and should be considered as part of a comprehensive malaria elimination strategy in specific settings.
© The American Society of Tropical Medicine and Hygiene.

Evidence Review Groups (ERGs)

Evidence Review Groups (ERGs) are expert groups convened for a limited time period to review a specific area of work, and to provide evidence-based information and options for recommendations. So far, the following ERGs have met under the umbrella of the MPAC.