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Areas of Research
Drug Targeting



Drug Delivery across the Skin




Publications
Comparison of diafiltration and tangential flow filtration for purification of nanoparticle suspensions.
Dalwadi, G., Benson, H.A.E. and Chen Y. (2005). Pharmaceutical Research, (in press).



Effect of lipophilic counter-ions on membrane diffusion of benzydamine.
Sarveiya, V., Templeton, J. F., Benson, H.A.E. (2005). European Journal of Pharmaceutical Science 26: 39-46 (in press).





Transdermal Drug Delivery: Penetration Enhancement Techniques.
Benson, H.A.E. (2005). Current Drug Delivery 2 (1): 22-33.



Influence of anatomical site and topical formulation on skin penetration of sunscreens.
Benson, H.A.E., Sarveiya, V., Risk, S., Roberts, M.S. (2005). Therapeutic Clinics Risk Management 1 (3): 209-218.



Skin penetration and systemic absorption of sunscreens after topical application.
Sarveiya, V., Risk, S., Benson, H.A.E. (2004). Journal of the American Academy of Dermatology 50(3): Supplement 1: P75.





Inclusion complexation of the sunscreen 2-hydroxy-4-methoxy benzophenone (oxybenzone) with hydroxypropyl-beta-cyclodextrin: Effect on membrane diffusion.
Sarveiya, V., Templeton, J.F., Benson, H.A.E. (2004). Journal of Inclusion Phenomena and Macrocyclic Chemistry 49(3-4): 275-281.





Ion-pairs of ibuprofen: increased membrane diffusion.
Sarveiya, V., Templeton, J.F., Benson, H.A.E. (2004). Journal of Pharmacy and Pharmacology 56(6): 717-724.





Influence of cyclodextrins on in vitro human skin absorption of the sunscreen, butyl-methoxydibenzoylmethane.
Simeoni, S., Scalia, S., Benson, H.A.E. (2004). International Journal Pharmacy 280(1-2): 163-71.



Amputees and phantom limb pain.
Benson, H.A.E. and Wright, A. (2004). Eds: Craighead W.E. & Nemeroff C.B: The Corsini Encyclopedia of Psychology and Behavioural Science (4th Ed), Wiley: N.Y.



Liquid chromatographic assay for common sunscreen agents: application to in vivo assessment of skin penetration and systemic absorption in human volunteers.
Sarveiya, V., Risk, S., Benson, H.A.E. (2004). Journal of Chromatography Bio-Analytical Technology, Biomedical Life Science 803(2): 225-31.





Drug delivery across the blood-brain barrier.
Chen, Y., Dalwadi, G. Benson, H.A.E., (2004). Current Drug Delivery 1: 361-376.




Transdermal Delivery of a Tetrapeptide: Evaluation of Passive Diffusion.
Benson, H.A.E., Caccetta, R., Chen, Y., Kearns, P. and Toth, I. (2003). Letters in Peptide Science 10(5-6): 615-620.



Can increasing the viscosity of formulations be used to reduce the human skin penetration of the sunscreen oxybenzone?
Cross, S.E., Jiang, R., Benson, H.A.E., Roberts, M.S. (2001). Journal of Investigative Dermatology 117(1): 147-150.



Assessment and clinical implications of absorption of sunscreens across skin.
Benson, H.A.E. (2000). American Journal of Clinical Dermatology 1(4): 217-224.



Ion-pair formation as a strategy to enhance topical delivery of salicylic acid.
Megwa, S.A., Benson, H.A.E., Cross, S.E., Roberts, M.S. (2000). Journal of Pharmacy and Pharmacology 52(8): 919-928.



Effect of ion pairing with alkylamines on the in-vitro dermal penetration and local tissue disposition of salicylates.
Megwa, S.A., Cross, S.E., Whitehouse, M., Benson, H.A.E., Roberts, M.S. (2000). Journal of Pharmacy and Pharmacology 52(8): 929-940.



Presentations
Rapid delivery of local anaesthetics by dermaportation: a novel skin penetration enhancement technology
Benson HAE, Caccetta R, Namjoshi S, Edwards J, Eijkenboom M. (2005) 11th World Congress on Pain, Sydney, Australia.



Dermal delivery enhancement by Dermaportation - a novel penetration enhancement technology.
Benson, H.A.E., Namjoshi, S. and Edwards, J. (2005). 39th Annual Conference of the Australian Society of Cosmetic Chemists, Brisbane.



Dermal penetration enhancement by Dermaportation - preliminary investigations of a novel technology.
Benson, H.A.E., Namjoshi, S. and Edwards, J. (2005). Australian Society of Dermatology Research Conference, Perth.



Enhanced skin penetration by peptide modification.
Caccetta R, Kearns P, Toth I, Benson HAE (2005). 6th Australian Peptide Conference, Queensland, Australia.



Characterisation of nanoparticles in the treatment of diabetic eye diseases.
Chen, Y., Dalwadi, G., Benson, H.A.E., Le, X., Poinern, G.E., Parkinson, G. and Ardery, W. (2005). 2nd SERI-ARVO meeting on Research in Vision and Ophthalmology, Singapore.



Characterisation and optimisation of nanopolymeric particles in the treatment of diabetic eye diseases.
Chen, Y., Dalwadi, G.,. Benson, H.A.E, Le, X., Poinern, G., Parkinson, G. and Ardery, W. (2005). 2nd SERI-ARVO meeting on Research in Vision and Ophthalmology, Singapore.



Skin penetration of biodegradable polymeric micro/nanoparticles.
Chen, Y., Wang, F. and Benson, H.A.E. (2005) 65th International Congress of FIP, Cairo, Egypt.



Stability of insulin in PLGA nanoparticles after complexation with protamine.
Chen, Y., Wang, F. and Benson, H.A.E. (2005) 65th International Congress of FIP, Cairo, Egypt.



In vitro evaluation of Naltrexone delivery across silastic membrane.
Krishnan G, Caccetta R, Benson HAE (2005). Australasian Pharmaceutical Sciences Association, Melbourne, Australia.



HPLC assay for 5-aminolevulinic acid and its application to assessment of skin penetration.
Namjoshi S, Caccetta R, Edwards J, Benson HAE (2005). Australasian Pharmaceutical Sciences Association, Melbourne, Australia.



Evaluation of factors contributing to the fast degradation of a hexapeptide-dalargin in release media.
Chan, P.H.H., Chen, Y. and Benson, H.A.E. (2004). Australasian Pharmaceutical Science Association Annual Conference, Melbourne.



Purification of Nanoparticles by Gel Filtration and Ultracentrifugation.
Dalwadi, G., Chen, Y., Lee, S.K. and Benson, H.A.E. (2004). 7th World Biomaterials Congress, Sydney.



Evaluating decontamination protocols and the effectiveness of PPE against exposure to micronised particles with sorbed toxic chemicals.
Lindars, E.S., Genovese, J.H., Wilkinson, S.P. Benson, H.A.E. (2004). AIOH Conference, Fremantle.



Enhancement of skin penetration by Dermaportation.
Namjoshi, S., Caccetta, R., Edwards, J. and Benson, H.A.E. (2004). Australasian Pharmaceutical Science Association Annual Conference, Melbourne.



Development and validation of HPLC assay of loperamide hydrochloride.
Patel, P., Dalwadi, G. Chen, Y. and Benson, H.A.E. (2004). Australasian Pharmaceutical Science Association Annual Conference, Melbourne.



Characterisation of Biodegradable PLGA Nanoparticles By Atomic Force Microscopy.
Poinern, G., Chen, Y., Benson, H.A.E., Jones, F., Richmond, B. and Parkinson, G. (2004). 7th World Biomaterials Congress, Sydney.



Influence of ion pairing on topical delivery of benzydamine.
Sarveiya, V.P., Templeton, J.F. and Benson, H.A.E. (2004). 9th International Perspectives in Percutaneous Penetration Conference, La Grande Motte, France.



Skin penetration of insulin-loaded PLGA nanoparticles.
Wang, F., Benson H.A.E. and Chen, Y. (2004). Australasian Pharmaceutical Science Association Annual Conference, Melbourne.



Transdermal Delivery of A therapeutic Peptide.
Benson, H.A.E., Caccetta, R., Chen, Y., Kearns, P. and Toth, I. (2003). 5th Australian Peptide Conference, Daydream Island, Queensland.



Controlled release of bovine insulin from hydrophilic biopolymer based microspheres.
Peng, L., Garlepp, M.J., Benson, H.A.E., Chen, Y. (2003). American Academy of Pharmaceutical Scientists, Salt Lake City, Utah.



Sustained Release of Human Recombinant Interleukin-2 from Dextran Sulfate Based Biodegradable Microspheres.
Peng, L., Garlepp, M.J., Chen, Y. and Benson, H.A.E. (2003). APSA Annual Conference, Bondi Beach, NSW Australia.



Chitosan nanoparticles prepared by coacervation.
Wang, F., Chen, Y. and Benson, H.A.E. (2003). APSA Annual Conference, Bondi Beach, NSW Australia.