Hi Rinnekin,Matt Dun's Lab would be coordinating the development...

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Rich&Poor

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10/02/23

10:32

Post #: 66174887
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Originally posted by Rinnekin: ↑

Hi R&P,

I did not see anything in the article that indicated that a combination of CAR-T and PNOC study drugs was considered.
Where did you find this?

My main take-away from this article is that, while CAR-T could be a promising future treatment alternative, it still has a long way to go and early trial results are far less promising than the initial reports from paxalisib mono or paxalisib and ONC201 combo in DIPG.

Talking about DIPG, the latest interview with JG in * was promising in my view when he said:
"We’ll have to look at the data and talk to agencies like the US FDA and the TGA here in Australia – but they are generally open to having these discussions,”
https://unauthorised investment advice/health/after-a-successful-4-5-million-cap-raise-and-with-cancer-trial-results-to-come-kazia-is-optimistic-for-2023/It indicates to me that regulatory discussions on paxalisib in DIPG can happen far sooner than at the end of the combo DIPG trial.

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Hi Rinnekin,

Matt Dun's Lab would be coordinating the development of a less toxic GD2 CAR T-cell therapy for H3K27M+ DIPG/DMG, in combination with ONC201 and paxalisib (PNOC study).
Matt Dun previously mentioned in his collaborative discussions that immunotherapy would be needed to knock out and kill the remaining cancer cells for DIPG/DMG.
I noticed a few months ago he was recruiting an additional lab assistant to research immunotherapy.
You can draw your own conclusion on his future research for DIPG/DMG.

Regards.

KZA Price at posting: 12.5¢ Sentiment: Buy Disclosure: Held
6 Upvote

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Hi Rinnekin,Matt Dun's Lab would be coordinating the development...

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