“Well, LNPs have gotten 10x more potent every year for the last 15 years so we must have reached homeopathic doses by now; and looking at the literature, AAV shuffling hasn't changed all that much since I completed my post-doc in an AAV lab in Stanford. Or maybe Jim Wilson has grown exceedingly gun-shy when he resigns from his well-paying function at AAV company Solid Biosciences over concerns of toxicity from high systemic AAV doses and possibly also his finding that delivery to a certain tissue in the mouse does not predict same delivery in humans.”
I would love to hear any inside chatter on how, or if, Benitec has already discovered ways to address these concerns/limitations. Just to hear the science behind it, really. That alone would boost my confidence.
BLT Price at posting:
21.5¢ Sentiment: Buy Disclosure: Held
