That's a fantastic 10 minute summary of just about anything an investor could want to know about the DurAVR from a doctor's perspective. And the new intro graphic is badass too.
I'd love to see a European trial if the money is there. It's been awhile, maybe a year, since I've heard Wayne mention it.
This is the first I've heard of valves pinwheeling but it's essentially the leaflets undergoing a rotational deformation when they close, which can affect durability as Dr Meduri stated. Here's a study done on the issue with some good illustrations of the pinwheeling:
Transcatheter valve underexpansion limits leaflet durability: implications for valve-in-valve procedures
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