BRAIN CANCER STUDY COMMENCES
Sydney, 1 February: Noxopharm announces that it has entered into a research agreement with the University of Hong Kong to conduct research into the use of the drug idronoxil (NOX66 active ingredient) to treat brain cancer.
In parallel to the NOX66 clinical program currently being rolled out, the Company has an extensive R&D program in place. This program involves a number of previously undisclosed oncology and non-oncology pre-clinical activities, all intended to add to the Company’s drug development pipeline. The Company previously has said that it will provide details of those R&D activities as confidentiality issues and patent lodgements allow. This is the first of those notifications.
The Hong Kong-based research activity has the objective of bringing idronoxil into the clinic for the treatment of both primary brain cancers (cancers arising within the brain) and secondary brain cancers (cancers arising outside of the brain and spreading to the brain). Such treatment of patients is made possible by the recent breakthrough in being able to get idronoxil to cross the blood-brain barrier and to enter the brain at high levels, as demonstrated in rats.
The collaboration with the university’s Faculty of Medicine aims to confirm the ability of idronoxil formulated as NOX66 to sensitise brain cancer cells to the chemotherapy drug temozolomide (TMZ). The eventual objective is to demonstrate that use of NOX66 will lead to significantly higher response rates to TMZ in both adult and paediatric brain cancers.
Malignant brain cancers remain one of the handful of cancer types that have shown virtually no change in overall survival outlook over the past 50 years. The need for precision therapy in light of the vital nature of the brain puts limitations on surgery and radiotherapy that generally don’t apply to other parts of the body, plus the mammalian blood-brain barrier ensures that the great majority of chemotherapy drugs are excluded from reaching the brain at effective levels. Of the 100-plus chemotherapy drugs available to oncologists, only 5 cross the blood-brain barrier and these form the backbone of chemotherapy of malignant brain cancers, with temozolomide the primary drug used. However, these drugs are poorly effective overall. For the main primary brain cancer in adults (glioblastoma), only 1 in 5 patients show any meaningful response, with that response typically being limited to several months. The results are even poorer with paediatric malignant brain cancers, along with adult secondary brain cancers (such as breast and lung cancer and melanoma). Malignant brain cancer remains a major frontier for drug development. ASX: NOX Noxopharm Limited ABN 50 608 966 123
