ems update in paladin energy annual report

INTERNATIONAL INITIATIVES

Malaria Control

Paladin has provided funding support to Eastland Medical Systems Limited for Eastland?s
development of ArTiMist?, a sub-lingual (under the tongue) spray for the treatment of severe and
complicated malaria in children. After completion of a successful clinical trial involving 30 children that
confirmed the effectiveness of the malaria treatment in young children, Eastland has moved on to a
150-patient multi centre superiority study in Africa. Trials have been progressing well with an initial 50
patients treated in Rwanda. The additional 100 patients are being recruited for treatment in the
Burkina Faso, Ghana and Tanzanian arms of the trial.