Great smoking phylomers, ds - I have found the smoking gun connecting Phylogica into the IO space, the hottest space in town.
Slide 43 Biotech Showcase San Francisco titled FPP-Omomyc decreases PD-L1 (Myc target gene)
• Increased cell death, decreased proliferation & PD-L1 expression in tumours treated with FPP-Omomyc versus FPP, Omomyc or vehicle controls
• Potential immuno-oncology implications
The slide also references the very same research paper which I previously made reference to - Myc regulates the antitumor immune response through CD47 and PD-L1. It was there all along but hidden in plain sight. Except that I don't think its hidden from potential collaborators.
My sense is that the work by Stanford University School of Medicine has ignited interest in the iMYC program and FPP-Omomyc construct by connecting the dots between Myc and PD-L1.
PYC Price at posting:
3.5¢ Sentiment: Buy Disclosure: Held
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(20min delay)