This NICE doc has some great response detail in it toofor...

This NICE doc has some great response detail in it too

for example

"The Committee was concerned by the post-hoc
stratification of the two key trials and other
uncertainties in the clinical evidence (See FAD
Sections 4.3, 4.5, 4.6, 4.8, 4.10), but concluded
that there was sufficient evidence of the clinical
effectiveness of mannitol to reach a decision"

"The Committee concluded that mannitol is clinically
effective in improving both lung function (FEV1) and
pulmonary exacerbations in people with cystic
fibrosis. The Committee further concluded that
there are subgroups of people who may experience
greater benefit from mannitol, such as people who
cannot use rhDNase, but that there is a degree of
uncertainty about the magnitude of any increased
clinical effectiveness."



http://www.nice.org.uk/nicemedia/live/12224/61227/61227.pdf