Hmmmm,
ANTIVIRAL COMPOUNDS AND METHODS - Biotron Limited
(Order Nidovirales, family Coronaviridae, Genus Coronavirus)
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0250019
Advantageous from a therapeutic perspective, the large +ssRNA genome of SARS-CoV-2 [1] also means the virus encodes a large number of proteins that may be potential drug targets: sixteen non-structural proteins (nsps), four structural proteins, and potentially nine accessory proteins (orfs) [2]. Primary searches for small molecule therapeutics have focused on the two main proteases encoded by SARS-CoV-2, nsp5 (Mpro) and nsp3 (PLpro) [3], and the major proteins of the RNA-dependent RNA-polymerase (RdRp) nsp12, and RdRp accessory proteins, nsp7 and nsp8 [2]. An overlooked target is nsp15, a protein associated with replication-transcription complexes that is conserved within the Nidovirales order with no corresponding host cellular counterpart.
https://www.freepatentsonline.com/y2019/0389816.html
ANTIVIRAL COMPOUNDS AND METHODS
Application Number:
16/554990
Publication Date:
12/26/2019
Filing Date:
08/29/2019
Export Citation:
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Assignee:
Biotron Limited (Sydney, AU)
A further well-known family of pathogenic viruses are the Coronaviruses. Coronaviruses (Order Nidovirales, family Coronaviridae, Genus Coronavirus) are enveloped positive-stranded RNA viruses that bud from the endoplasmic reticulum-Golgi intermediate compartment or the cis-Golgi network (Fischer, Stegen et al. 1998; Maeda, Maeda et al. 1999; Corse and Machamer 2000; Maeda, Repass et al. 2001; Kuo and Masters 2003)
Coronaviruses infect humans and animals and it is thought that there could be a coronavirus that infects every animal. The two human coronaviruses, 229E and OC43, are known to be the major causes of the common cold and can occasionally cause pneumonia in older adults, neonates, or immuno compromised patients (Peiris, Lai et al. 2003). Animal coronaviruses can cause respiratory, gastrointestinal, neurological, or hepatic diseases in their host (Peiris, Lai et al. 2003). Several animal coronavirus are significant veterinary pathogens (Rota, Oberste et al. 2003).
Severe acute respiratory syndrome (SARS) is caused by a newly identified virus. SARS is a respiratory illness that has recently been reported in Asia, North America, and Europe (Peiris, Lai et al. 2003). The causative agent of SARS was identified as a coronavirus. (Drosten, Gunther et al. 2003; Ksiazek, Erdman et al. 2003; Peiris, Lai et al. 2003). The World Health Organization reports that the cumulative number of reported probable cases of SARS from 1 Nov. 2002 to the 11 Jul. 2003 is 8,437 with 813 deaths, nearly a 10% death rate. It is believed that SARS will not be eradicated, but will cause seasonal epidemics like the cold or influenza viruses (Vogel 2003).
To improve the prospect of treating and preventing viral infections,
there is an on-going need to identify molecules capable of inhibiting various aspects of the viral life cycle.
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