Why is FerriScan better than other tests?
FerriScan VS liver biopsy
Liver biopsy is an invasive and painful procedure which cannot be performed frequently. There is a high risk of sampling error due to significant heterogeneity of iron concentrations throughout the liver. The biopsy results may also be affected by the presence of other liver diseases.
FerriScan VS liver T2*
While the liver T2* test has relatively good sensitivity and specificity of LIC at 3.2 mg/g it has less satisfactory results at other clinically important threshold such as 7.0 mg/g. 7.0 mg/g is the upper limit of optimal range for LIC and increased risk of iron-induced complications and 15.0 mg/g, a threshold for greatly increased risk for cardiac disease and early death in patients with transfusional iron overload. The Liver T2* results may also be affected by the presence of liver fibrosis. FerriScan results are not affected by the presence of liver fibrosis. [7]
FerriScan VS serum ferritin
There is a weak correlation between serum ferritin and body iron stores as serum ferritin results are confounded by factors such as inflammation. Serum ferritin can only be used for monitoring trends in a patient's iron loading and does not give quantitative reliable information on the degree of iron loading.
FerriScan VS Gandon method
Although the Gandon method is a simple technique to use, a weak correlation has been demonstrated in patients with a LIC above 11.2 mg/g dw. [5] Patients with iron overload may have a LIC considerably above this level.
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