It has been well documented that Coramsine down regulates the...

It has been well documented that Coramsine down regulates the cytokyne interlukin6. IL6 is responsible swelling and feeling bad among other things. Coramsine is being considered as a palative treatment for this reason I think. A huge market.
Researchers at MLNM(Nasdaq)found an interesting result of IL6 reduction some time back. This could open up all sorts of interesting prospects for Coramsine.
> > >Abstract
> > >
> > >The ubiquitin-conjugating enzyme CDC34 (UBC3) is linked to cell cycle
> > >progression in diverse cell types; however, its role in multiple myeloma
> > >(MM) pathogenesis is unclear. Here, we show that CDC34 is highly expressed
> > >in patient MM cells and MM cell lines versus normal cells. Blocking CDC34
> > >using a dominant-negative strategy enhances the anti-MM activity of
> > >Bortezomib/Proteasome inhibitor PS-341, dexamethasone (Dex) and
> > >2-Methoxyestradiol (2ME2). The expression of wild-type CDC34 reduces
> > >Dex-induced cytotoxicity in MM cells. Moreover, inhibition of CDC34
> > >enzymatic activity abrogates interleukin-6-induced protection against
> > >Dex-induced apoptosis. Together, these findings provide evidence that (1)
> > >CDC34 expression is associated with growth and survival of MM
> cells and (2)
> > >blocking CDC34 activity not only enhances anti-MM activity of Bortezomib
> > >and 2ME2 but also overcomes IL-6-triggered Dex-resistance.
> > >
Assay tests in the US have indicated Coramsine can improve the performance of some chemos.
Good luck to Solbec holders.