To us ATH investors iron chelation is the method slowing down ferroptosis. Here is a review of ferroptosis inhibitors. It tells us about ferroptosis in neuroimmune diseases, T-cells, B-cells neutrophils, etc., which relate to how long we will live.

Highlight

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  Summarized the mechanisms and pathways of ferroptosis, and its susceptibility to environmental factors.

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  Clarified the potential role of ferroptosis in neuroimmune and neurodegenerative diseases.

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  Provided an overview of the localization of ferroptosis in immune and neural cells of CNS immune and degenerative diseases.

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  Presented a summary of ferroptosis inhibitors for novel therapeutic development.

Review

Biomed Pharmacother

. 2024 May 24:176:116777.

doi: 10.1016/j.biopha.2024.116777. Online ahead of print.

Targeting ferroptosis in neuroimmune and neurodegenerative disorders for the development of novel therapeutics

Zihao Li ¹, Ye Zhang ², Meiling Ji ³, Chenglong Wu ¹, Yanxing Zhang ⁴, Senlin Ji ⁵

Affiliations expand

• PMID: 38795640

DOI: 10.1016/j.biopha.2024.116777Free article

Abstract

Neuroimmune and neurodegenerative ailments impose a substantial societal burden. Neuroimmune disorders involve the intricate regulatory interactions between the immune system and the central nervous system. Prominent examples of neuroimmune disorders encompass multiple sclerosis and neuromyelitis optica. Neurodegenerative diseases result from neuronal degeneration or demyelination in the brain or spinal cord, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. The precise underlying pathogenesis of these conditions remains incompletely understood. Ferroptosis, a programmed form of cell death characterised by lipid peroxidation and iron overload, plays a pivotal role in neuroimmune and neurodegenerative diseases. In this review, we provide a detailed overview of ferroptosis, its mechanisms, pathways, and regulation during the progression of neuroimmune and neurodegenerative diseases. Furthermore, we summarise the impact of ferroptosis on neuroimmune-related cells (T cells, B cells, neutrophils, and macrophages) and neural cells (glial cells and neurons). Finally, we explore the potential therapeutic implications of ferroptosis inhibitors in diverse neuroimmune and neurodegenerative diseases.



https://www.sciencedirect.com/science/article/pii/S0753332224006619?via%3Dihub