ATH434 is an iron chelator targeting overload of iron found in PD, as well as in AD and Huntington disease, however, at present, we do not have human studies to demonstrate the efficacy in these diseases. With this paper, it is perhaps easy to imagine if ATH434 could be used as a stroke drug.
In strokes, there will be local bleeding into the brain, and with it too much iron leaks into the brain cells. These cells suffer from this iron overload, and many of these cells die. Happens ferroptosis.

This review tells about how iron overload kills the neurons in strokes and it is very similar to what happens in PD, AD, and HD. As we all know, strokes are common in elderly populations. Recovery after stroke is often slow and incomplete. Better drugs are needed and perhaps ATH434 is one possibility as it is an iron chelator eliminating iron causing ferroptosis.

This is a free paper. The abstract is too short to tell the main things but the paper itself is good.

Front Cell Neurosci

. 2021 Jun 3;15:615372.

doi: 10.3389/fncel.2021.615372. eCollection 2021.

Ferroptosis and Its Multifaceted Roles in Cerebral Stroke

Yongfa Zhang ¹, Xiaoyang Lu ^{2 3}, Bai Tai ¹, Weijia Li ¹, Tao Li ¹

Affiliations expand

• PMID: 34149358

PMCID: PMC8209298 DOI: 10.3389/fncel.2021.615372

Abstract

Ferroptosis is a unique regulated cell death defined by the intracellular iron overload and distinct biological features compared with other well-known programmed cell death. Ferroptosis can be triggered by many causes including decreased expression of glutathione (GSH), inhibition of the function of glutathione-dependent peroxidase 4 (GPX4), and system x_c ^-, all of which finally lead to the over-accumulation of lipid peroxides in the cell. Ferroptosis has been reported to play an important role in the pathophysiological process of various cancers. In recent years, much evidence also proved that ferroptosis is involved in the progress of cerebral stroke. In this review, we summarized the characteristics of ferroptosis and the potential relationship between ferroptosis and ischemic and hemorrhagic stroke, to provide new targets and ideas for the therapy of stroke.