Ferroptosis in strokes, page-2

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larrybird33

18 Posts.

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22/06/21

23:12

Post #: 54002397
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Originally posted by pivalde: ↑

ATH434 is an iron chelator targeting overload of iron found in PD, as well as in AD and Huntington disease, however, at present, we do not have human studies to demonstrate the efficacy in these diseases. With this paper, it is perhaps easy to imagine if ATH434 could be used as a stroke drug.
In strokes, there will be local bleeding into the brain, and with it too much iron leaks into the brain cells. These cells suffer from this iron overload, and many of these cells die. Happens ferroptosis.

This review tells about how iron overload kills the neurons in strokes and it is very similar to what happens in PD, AD, and HD. As we all know, strokes are common in elderly populations. Recovery after stroke is often slow and incomplete. Better drugs are needed and perhaps ATH434 is one possibility as it is an iron chelator eliminating iron causing ferroptosis.

This is a free paper. The abstract is too short to tell the main things but the paper itself is good.

.2021 Jun 3;15:615372.
doi: 10.3389/fncel.2021.615372.eCollection 2021.
Ferroptosis and Its Multifaceted Roles in Cerebral Stroke
Yongfa Zhang¹, Xiaoyang Lu²³, Bai Tai¹, Weijia Li¹, Tao Li¹
Affiliations
PMID:34149358
PMCID:PMC8209298DOI:10.3389/fncel.2021.615372
Abstract
Ferroptosis is a unique regulated cell death defined by the intracellular iron overload and distinct biological features compared with other well-known programmed cell death. Ferroptosis can be triggered by many causes including decreased expression of glutathione (GSH), inhibition of the function of glutathione-dependent peroxidase 4 (GPX4), and system x_c^-, all of which finally lead to the over-accumulation of lipid peroxides in the cell. Ferroptosis has been reported to play an important role in the pathophysiological process of various cancers. In recent years, much evidence also proved that ferroptosis is involved in the progress of cerebral stroke. In this review, we summarized the characteristics of ferroptosis and the potential relationship between ferroptosis and ischemic and hemorrhagic stroke, to provide new targets and ideas for the therapy of stroke.

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Thanks for posting all this new research, pivalde. I would like to add, iron overload/iron dyshomeostasis is thought to be part of the pathogenesis of sars-cov2. In fact, new research is bringing forward the idea that gray-matter reduction in Covid patients may be due to a change in iron homeostasis. My question to you and the board is, "what is David Stamler doing about any of this interesting research?" Can he apply for NIH grants or grants from any other countries to test ATH in some of these indications? Can he find a partner to run trials in these indications? Frankly, I would like to see him do something....anything to develop and expand the pipeline/indications.

link to brain iron gray matter - https://www.auntminnieeurope.com/index.aspx?sec=ser&sub=def&pag=dis&ItemID=620223
ATH Price at posting: 2.8¢ Sentiment: Buy Disclosure: Held
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