Five percent dextrose maximizes dose delivery

https://www.ncbi.nlm.nih.gov/pubmed/28105342

Old news, but good to see Pubmed doing it. Dextrose has been included everywhere leave the US for some years now.


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Abstract

Resin Yttrium-90 (Y90) microspheres have historically been infused using sterile water (H₂O). In 2013, recommendations expanded to allow delivery with 5% dextrose in water (D₅W). In this retrospective study, we hypothesized that D₅W would improve Y90 delivery with a lower incidence of stasis. We reviewed 190 resin Y90 infusions using H₂O (n=137) or D₅W (n=53). Y90 dosimetry was calculated using the body surface area method. Infusion was halted if intra-arterial stasis was fluoroscopically identified prior to clearing the vial. Differences between H₂O and D₅W groups were calculated for activity prescription, percentage of cases reaching stasis, and percentage delivery of prescribed activity using z- and t-test comparisons, with α=0.05. Thirty-one of 137 H₂O infusions developed stasis compared to 2 of 53 with D₅W (z=3.07, p=1.05E-03). D₅W also had a significantly higher prescribed activity than H₂O [28.2 millicuries (mCi) vs. 20.4 mCi, respectively; t=5.0, p=1.1E-6]. D₅W had a higher delivery percentage of the prescribed dose compared to H₂O (101.5 vs. 92.7%, respectively; t=3.8, p=1.92E-4). In conclusion, resin microsphere infusion utilizing D₅W has a significantly lower rate of stasis than H₂O and results in more complete dose delivery. D₅W is preferable to H₂O for resin microsphere infusion.'