Very interesting thoughts mac9 on the vitamin D - modern avoidance of sun linkage.
I am very interested in meta studies (and especially regional disparities) with regards trying to determine causes for diseases that are currently cause unknown. This was inspired at school by a teacher who highlighted (not tested the veracity of this story) how cholera was found by a doctor in the 19th century to be more prevalent near the cemetery where they buried victims and was infiltrating the water supply (bacterial).
Autism is also increasing in incidence rate and has regional disparities of incidence rate in the US with the mid-west states having up to twice the incidence rate as states on the coast (from memory).
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