There are sure multiple good signs. You may not know, but in...

There are sure multiple good signs. You may not know, but in their reach2HD trial the small sample(4 patients) they checked for brain atrophy over the trial showed the chelator they were using did slow brain atrophy. That was not an endpoint, and so small that nobody took much notice. There were some stat sig improvement on an executive function endpoint of Trial Making Test B. That was the more difficult test between A&B. That drug PBT2 was a zinc chelator, but also attracted other metals including iron.I am not going to argue the merits of Reach2HD, but just want to point out that there was a reduction in brain atrophy seen there, which is now more interesting.
Executive function is the ability to think fast, eg champion soccer players have very high scores in executive function.