Skint, this paper??: Florian Krismer et al where they found...

Skint, this paper??: Florian Krismer et al where they found "Brain regions chiefly affected by MSA pathology showed progressive atrophy with annual rates of atrophy for the cerebellar cortex, cerebellar white matter, pons, and putamen of −4.24 ± 6.8%, −8.22 ± 8.8%, −4.67 ± 4.9%, and − 4.25 ± 4.9%, respectively.
https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.29633

I have not seen this paper earlier but it is important just for the Open study because these patients had had the disease for 4,1 years (mean) and in the Open study for over 3 years. Cerebellar white matter seems to be the best biomarker with an annual atrophy rate of 8%. It should also be measured in the open study.

Thanks, Skint!