It appears the magnitude of their interest is significant. "The...

It appears the magnitude of their interest is significant.

"The lab began working on the CS1 and CS2 projectthree years ago when Chen first arrived at City of Hope."

"Because CS1 (bisantrene) and CS2 (brequinar) have been tested in multiple clinical trials under the guises of other objectives, Chen and his colleagues believe this basic research has access to a freeway entrance that will fast track it into clinical trials. The National Institutes of Health (NIH) have already funded the next step: The Chen lab is working to further optimize CS1 and CS2 to develop improved FTO inhibitor compounds that are more efficacious with minimal side effects for humans."

“The cancer inhibitors we developed are at least 10 times more effective in killing acute myeloid leukemia cells than several previously reported FTO inhibitors,” said Jianjun Chen, Ph.D."

"In the study, City of Hope scientists demonstrated that the two new FTO inhibitor compounds they created had potent anti-tumor effects and substantially improved overall survival in mice with AML or a solid tumor such as breast cancer."


https://www.cityofhope.org/breakthroughs/two-mighty-new-molecules-may-kill-cancer-cells-others-cant