Australia's largest stock trading and investment forum Australia's #1 stock forum

RAC

Click for more information

0.40%

$1.23 race oncology ltd

Does that mean the IC50 values for the Melanoma preclinical...

First 4328 Last

Share
Profile

Follow
ttn2

90 Posts.

13

08/11/21

16:26

Post #: 57402668
Share

Originally posted by RaceOncology: ↑

The issue really revolves around the use of Zantrene pulled straight from the clinic. Chemicals labeled for the clinic are labelled very differently to those that are used in the laboratory. The cause of the issue here is that the clinical material is labeled as it contained 250mg of bisantrene, not 295mg bisantrene dihydrochlroride salt. For use in the clinic you want to keep the labels as simple as possible, but it creates issues for scientists as this is not clear.

The end of the day the IC50 numbers were all 20% better than originally reported to us. It makes no difference with use in the clinic as the dose given to a patient is driven by the maximal tolerated dose (MTD) (320mg/m2), but it does make Zantrene even better than was originally thought.

When you compare Zantrene to Doxorubicin you should keep in mind that the MTD of Zantrene is 8x higher than doxorubicin so you can give 8x more. If the two drugs have similar IC50 numbers then is Zantrene is really 8x better.

Expand

Does that mean the IC50 values for the Melanoma preclinical should also be 20% lower? or was the calculation issue already corrected by then?

RAC Price at posting: $3.28 Sentiment: Buy Disclosure: Held
8 Upvote

0 Great analysis

Reply

There are more pages in this discussion • 6,555 more messages in this thread...

First 4328 Last

Add RAC (ASX) to my watchlist

(20min delay)
Last $1.23		Change -0.005(0.40%)		Mkt cap ! $204.3M

Open	High	Low	Value	Volume
$1.25	$1.25	$1.21	$120.5K	97.77K

Buyers (Bids)

No.	Vol.	Price($)
2	991	$1.23

Sellers (Offers)

Price($)	Vol.	No.
$1.25	2409	1

View Market Depth

No.	Vol.	Price($)
2	991	1.230
1	700	1.220
1	36284	1.210
4	109837	1.200
1	3500	1.180

Price($)	Vol.	No.
1.250	2409	1
1.255	4000	1
1.295	5256	1
1.300	11257	3
1.320	1000	1

Last trade - 16.10pm 02/05/2024 (20 minute delay)


Last $1.24			Change -0.005 ( 0.40 %)
Open	High		Low	Volume
$1.24	$1.25		$1.21	17303
Last updated 15.51pm 02/05/2024 ?

RAC (ASX) Chart