General discussion, page-19931

'Acetazolamide is the most studied medication for sleep disturbances at altitude as well as for treating acute mountain sickness (AMS). Its primary action is the enzymatic inhibition of CO2 to carbonic acid in a wide array of sites, including kidney, peripheral chemoreceptors, red blood cells, and brain.'

https://www.incannex.com/https-sleepreviewmag-com-sleep-disorders-breathing-disorders-obstructive-sleep-apnea-dronabinol-synthetic-thc-strong-contender-for-first-sleep-apnea-pill/

this from the study
The study found that just 2.5 mg of dronabinol and 125 mg of acetazolamide decreases the number of times that breathing is disrupted throughout the night better in people with sleep apnea than if each ingredient was administered independently. Though acetazolamide can cause excessive urination, that side effect has not appeared at this dose, and the low dose of synthetic THC is not enough to lead to intoxication.
The drug combination cut the apnea hypopnea index (AHI) of patients with moderate to severe sleep apnea by an average of just over 50%,1 a leap from the 33% drop seen when dronabinol is taken alone.2 The results support the researchers’ hypothesis that the ingredients work synergistically to reduce apneas.
At least 14 clinical trials have looked at acetazolamide as a potential treatment for sleep-disordered breathing with encouraging results.3 The new trial results make the case for using acetazolamide in combination with dronabinol.

importantly the Incannex results support the supposition