General discussion, page-6155

Though not a blind study and no control group, its pretty sound method and supervision was appropriate for psychology standards.

its interesting that they chose escitalopram for the comparison. more interesting they gave a 1mcg dose to the escitalopram group. I dare say they would have taken blood samples during and after the doses to check metabolism and interactions with the anti-depressant. though this isn't mentioned. https://www.nejm.org/doi/full/10.1056/NEJMoa2032994