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Hi, this is just an update as l agree my detail may have been a bit light. My apologies. ln my opinion a couple of situations may occur. First being there would be a number of second tear large investors waiting to elevate their holding, they sit in a Midships position waiting for the Phase 2 to get the go ahead and in this case the Safety is off their minds as Miles Prince seems very comfortable in regard to safety at this stage. l believe with the potential of PTX100 these investors will elevate their holdings substantially which traditionally they are likely to top up from the open market. And l don't think any of the top 20 will have a say in this including myself. And l think it is important to remember that there are Pharmaceutical Companies siting in the wind and they don't miss a trick and their timing to load up is impeccable. And in regard to your question Shellbell l believe the average prior treatments were 4 - 5.5 for the process of Phase 1, and l have done the figures on Phase 2 only needing 2 prior treatments. Remembering this is only my opinion, regards Logan123.