Yep he has been very consistent with this message about lower dosages having less efficacy
Most of the market seems to have missed the key implications - including me!
Refer to 23min mark - also gives good recap of FDA strict protocols and reasoning for staged approach
https://www.youtube.com/watch?v=VDVI6QwXEX4
p.s. Thought John Hester's prompting PR at end was perhaps the highlight. I've seen introverts with a stutter do more compelling Toast Master ice breakers than PR
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