Here's another Chinese study using shRNA for lung cancer:
http://www.ijcep.com/files/ijcep1208008.pdf
"This study injected lentivirus-delivered livinshRNA into established xenograft tumors derived from the lung adenocarcinoma cell line SPC-A-1 in BALB/C nude mice, the result showed that LivinshRNA down-regulated Livin expression effectively, induced tumor cell apoptosis, reduced tumor cell proliferation, and suppressed tumor growth dramatically"
"Recent studies demonstrated that down-regulation of Livin expression by small interfering RNAs (siRNA) is effective in sensitizing cancer cells to treatment modalities and may emerge as a promising new therapy. Lentiviral delivery of interfering RNA (RNAi) can effectively and steadily silence gene expression, which can remedy the problem of the short half-life of these molecules in other RNAi systems [19]. Thus, lentiviral delivery of RNAi candidate drugs should overcome problems related to chemical stability and drug delivery and may be used as therapeutic agents"
"The Livin mRNA has two isoforms: a and ß. Overexpression of this gene has been found in various tumors, including melanoma, breast, cervical, colon and prostate cancers, and leukemia"
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