Its good to know hydroxyquinolines are known for having great...

Its good to know hydroxyquinolines are known for having great antibacterial and antifungal properties.


Despite what the Dr Suess clowns say

252-74
8-Hydroxyquinolines in medicinal chemistry: A structural perspective
Oliveri, V; Vecchio, G
8-Hydroxyquinolines are heterocyclic compounds characterized by a moderate metal-binding affinity. The interest in 8-hydroxyquinolines has grown exponentially in the last two decades as they are privileged structures for the design of new drug candidates that exert a host of biological effects on various targets. The study of biological activities such as neuroprotection, anticancer, antibacterial, antifungal activity has been further promoted by the synthetic versatility of 8-hydroxyquinoline, which allows the generation of a large number of derivatives. These include numerous multifunctional analogues having the metal-binding motif of 8-hydroxyquinoline. In this review, we have summarized 8-hydroxyquinolines, 8-hydroxyquinoline-like compounds, 8-hydroxyquinoline-loaded nanoparticle systems with respect to their biological activities, interaction with metal ions and mechanisms of action.
2016 Elsevier Masson SAS. All rights reserved.