MSB 4.66% $1.46 mesoblast limited

GVHD in US, page-30

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    You’ve made some good points about where MSCs should sit in the scheme of things. However there’s a lot of steroid bashing on the MSB pages, I thought I’d share my opinion on some of these points.


    1. I’m not sure where this myth of stem cells being ‘natural’ came from. I don’t see how taking someone else’s stem cells and injecting them in a patient is any more natural than steroids - considering that cortisol is a naturally occurring I would think hydrocortisone is at least as ‘natural’ as stem cells.

    2. Steroids are prescribed because they work. And in short courses they are extremely safe. Take asthma for example. They are also very cheap and easily admistered orally.


    3. Side effects of steroids occur universally with long term use - hence the constant quest for steroid sparing agents. Drugs like methotrexate and biological agents are used essentially to reduce long term prednisone use. I can’t comment on MSCs as potential disease modifying agents in IBD or RA but would be interested to see any results. The issue would be competing with a market saturated with proven and effective antibody based treatments.

    3. Chronic autoimmune and inflammatory diseases won’t be cured by MSCs just as they are not cured by steroids.


    4. I think the best indication for MSCs is in MSK diseases like chronic back pain and osteoarthritis given that they have inflammatory components to their pathology but are predominantly degenerative. I am waiting in anticipation for the read out for chronic back pain.


    i‘m happy to be proven wrong or corrected on any of the above points. However I think it’s important to keep expectations of the potential of MSCs realistic.

    Last edited by AllanHU: 07/01/19
 
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