h275y mutation - aus data on who website

So the government has out of date Tamiflu - what will they do? - order more Tamiflu or replace with Relenza - hmmm seems like a tough decision .....

Preliminary summary on oseltamivir- resistant H1N1 virus: Australia

Reporting date: 23 December 2008

Influenza activity in Australia during 2008 southern hemisphere season was moderate with the majority of viruses detected being of either influenza B or influenza A(H3N2) type/subtype. 115 influenza A(H1N1) viruses have been received at the WHO Collaborating Centre in Melbourne
and were analysed for antiviral sensitivity. Of these, 108 (94%) viruses were confirmed to possess the specific mutation (H275Y) that confers high-level resistance to oseltamivir. These strains remained fully sensitive to zanamivir and sequence analysis of the M2 gene found that
these strains do not have mutations associated with adamantane resistance.

Table: Oseltamivir-resistant A(H1N1) virus (1st April to 23rd December 2008)
# Australian A(H1N1) viruses
tested 115
# Australian A(H1N1) viruses
with H275Y mutation (%)
Australia 108 (94%)

Cheers MJ